Journal article
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
- Abstract:
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The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incompletely understood. Here we identify sequence signatures enriched in genomic p53-binding sites modulated by the transcription cofactor iASPP. Moreover, our p53–iASPP crystal structure reveals that iAS...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.8MB)
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- Publisher copy:
- 10.1073/pnas.1909393116
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Authors
Funding
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 116
- Issue:
- 35
- Pages:
- 17470-17479
- Publication date:
- 2019-08-08
- Acceptance date:
- 2019-07-11
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Source identifiers:
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1031509
Item Description
- Keywords:
- Pubs id:
-
pubs:1031509
- UUID:
-
uuid:3d32eed3-c4cd-455b-a410-9b1966af012e
- Local pid:
- pubs:1031509
- Deposit date:
- 2019-07-12
Terms of use
- Copyright holder:
- Chen et al
- Copyright date:
- 2019
- Notes:
-
Copyright © 2019 the Authors. Published by PNAS.
This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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