Journal article icon

Journal article

A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

Abstract:

The safety, immunogenicity, and efficacy of DNA and modified vaccinia virus Ankara (MVA) prime-boost regimes were assessed by using either thrombospondin-related adhesion protein (TRAP) with a multiple-epitope string ME (ME-TRAP) or the circumsporozoite protein (CS) of Plasmodium falciparum. Sixteen healthy subjects who never had malaria (malaria-naive subjects) received two priming vaccinations with DNA, followed by one boosting immunization with MVA, with either ME-TRAP or CS as the antigen...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/iai.00590-06

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Expand authors...
Journal:
Infection and immunity
Volume:
74
Issue:
10
Pages:
5933-5942
Publication date:
2006-10-01
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Source identifiers:
1418
Language:
English
Keywords:
Pubs id:
pubs:1418
UUID:
uuid:3d5e2d0d-e1ea-4023-92de-375f8deefc95
Local pid:
pubs:1418
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP