Modelling toehold-mediated RNA strand displacement.
We study the thermodynamics and kinetics of an RNA toehold-mediated strand displacement reaction with a recently developed coarse-grained model of RNA. Strand displacement, during which a single strand displaces a different strand previously bound to a complementary substrate strand, is an essential mechanism in active nucleic acid nanotechnology and has also been hypothesized to occur in vivo. We study the rate of displacement reactions as a function of the length of the toehold and temperat...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
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- Copyright holder:
- Biophysical Society
- Copyright date:
- Copyright © 2015 by the Biophysical Society.
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