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Thesis

Understanding the link between interleukin 17 and vaccine-induced protection in tuberculosis

Abstract:

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (M.tb), remains a global health problem and although BCG offers some protection against childhood disseminated disease and other mycobacterial infections, its efficacy against pulmonary TB varies between 0 and 80%. Modified Vaccinia virus Ankara expressing antigen 85A (MVA85A) is a novel TB vaccine designed to boost mycobacterium-specific CD4+ T cell response primed by BCG. MVA85A induces strong interferon (IFN...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Jenner Institute - McShane Lab
Oxford college:
Lincoln College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Griffiths, K
Grant:
WT086338RP
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:3d7f5e42-59b8-4fda-a1a8-6a764ea219df
Local pid:
ora:10662
Deposit date:
2015-03-19

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