Journal article
Hydrodynamic gene delivery of CC chemokine binding Fc fusion proteins to target acute vascular inflammation in vivo.
- Abstract:
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Blockade of CC chemokines is an attractive yet under utilized therapeutic strategy. We report the in vivopharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. We demonstrate that the in vivoefficacy of the protein can be interrogated using hydrodynamic gene delivery of a standard mammalian expression plasmid. High plasma levels of the 35 K-Fc protein are maintained for at least 14 days post gene transfer, with the protein still detecta...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1038/srep17404
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publisher's website
- Journal:
- Scientific reports Journal website
- Volume:
- 5
- Pages:
- 17404
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
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2045-2322
- ISSN:
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2045-2322
- Source identifiers:
-
580231
Item Description
- Language:
- English
- Pubs id:
-
pubs:580231
- UUID:
-
uuid:3d874a2a-e1a0-4f2e-b91f-cf1eb61a5afb
- Local pid:
- pubs:580231
- Deposit date:
- 2016-01-04
Terms of use
- Copyright holder:
- McNeill et al
- Copyright date:
- 2015
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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