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Journal article

Hydrodynamic gene delivery of CC chemokine binding Fc fusion proteins to target acute vascular inflammation in vivo.

Abstract:

Blockade of CC chemokines is an attractive yet under utilized therapeutic strategy. We report the in vivopharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. We demonstrate that the in vivoefficacy of the protein can be interrogated using hydrodynamic gene delivery of a standard mammalian expression plasmid. High plasma levels of the 35 K-Fc protein are maintained for at least 14 days post gene transfer, with the protein still detecta...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep17404

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Expand authors...
Publisher:
Nature Publisher's website
Journal:
Scientific reports Journal website
Volume:
5
Pages:
17404
Publication date:
2015-01-01
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
580231
Language:
English
Pubs id:
pubs:580231
UUID:
uuid:3d874a2a-e1a0-4f2e-b91f-cf1eb61a5afb
Local pid:
pubs:580231
Deposit date:
2016-01-04

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