Journal article icon

Journal article

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

Abstract:

Background

Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence. The current WHO guideline recommends excluding these individuals with indeterminate outcomes in a complete case (CC) analysis. Data from the four artemisinin-based combination (4ABC) trial was used to compare the perfo... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1186/s12874-019-0856-z

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-2158-846X
More by this author
Role:
Author
ORCID:
0000-0002-1713-6209
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-6008-2963
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-2000-2874
Expand authors...
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medical Research Methodology Journal website
Volume:
19
Article number:
215
Publication date:
2019-11-27
Acceptance date:
2019-10-21
DOI:
EISSN:
1471-2288
Source identifiers:
1074954
Language:
English
Keywords:
Pubs id:
pubs:1074954
UUID:
uuid:3d92b1a7-e5e7-40e5-8fc8-19fa07f3f9b8
Local pid:
pubs:1074954
Deposit date:
2019-11-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP