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Journal article

One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

Abstract:

Many promising vaccine candidates from pathogenic viruses, bacteria, and parasites are unstable and cannot be produced cheaply for clinical use. For instance, Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is essential for erythrocyte invasion, is highly conserved among field isolates, and elicits antibodies that neutralize in vitro and protect in an animal model, making it a leading malaria vaccine candidate. However, functional RH5 is only expressible in eukaryotic sys...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1616903114

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Funding agency for:
Campeotto, I
Grant:
106917/Z/15/Z
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Funding agency for:
Draper, S
Grant:
106917/Z/15/Z
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Funding agency for:
Higgins, M
Grant:
106917/Z/15/Z
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Funding agency for:
Fleishman, S
Grant:
106917/Z/15/Z
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Funding agency for:
Fleishman, S
Grant:
106917/Z/15/Z
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Science Journal website
Volume:
114
Issue:
5
Pages:
998-1002
Publication date:
2017-01-31
Acceptance date:
2016-12-16
DOI:
ISSN:
1091-6490
Source identifiers:
671733
Language:
English
Keywords:
Pubs id:
pubs:671733
UUID:
uuid:3da9cfb8-edef-499c-94de-93967db6107b
Local pid:
pubs:671733
Deposit date:
2017-02-07

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