Thesis
Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies
- Abstract:
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Though antibodies as therapeutics are limited to extracellular targets, their repertoire of molecular interactions has particular relevance to the many intracellular cellular proteins for which small molecule screening has reached impasse. For such proteins there is little recourse to theory, since molecular recognition is, in practical terms, still not well understood. Here I apply antibody discovery to the lysine demthylases KDM4D and PHF8, two proteins difficult to inhibit selectively...
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Authors
Contributors
+ Schofield, C
Role:
Supervisor
+ Brennan, P
Role:
Supervisor
+ Lawson, A
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:3dac2184-9532-49a4-aa7b-b06653d44a8c
- Deposit date:
- 2018-05-26
Terms of use
- Copyright holder:
- Wolfreys, F
- Copyright date:
- 2017
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