Thesis icon

Thesis

Inhibition of KDM4D and stabilisation of the PHF8 plant homeodomain’s transient structural states using antibodies

Abstract:

Though antibodies as therapeutics are limited to extracellular targets, their repertoire of molecular interactions has particular relevance to the many intracellular cellular proteins for which small molecule screening has reached impasse. For such proteins there is little recourse to theory, since molecular recognition is, in practical terms, still not well understood. Here I apply antibody discovery to the lysine demthylases KDM4D and PHF8, two proteins difficult to inhibit selectively...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Biomedical Services
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
More from this funder
Funding agency for:
Wolfreys, F
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3dac2184-9532-49a4-aa7b-b06653d44a8c
Deposit date:
2018-05-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP