A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Recognition of antigen by T cells requires the formation of a specialized junction between the T cell and the antigen-presenting cell. This junction is generated by the recruitment and the exclusion of specific proteins from the contact area. The mechanisms that regulate these events are unknown. Here we demonstrate that ligand engagement of the adhesion molecule, CD2, initiates a process of protein segregation, CD2 clustering, and cytoskeletal polarization. Although protein segregation was n...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 483.6KB)
- Publisher copy:
- Local pid:
- Deposit date:
- Copyright holder:
- Cell Press
- Copyright date:
- Copyright © 1998 by Cell Press. Under an Elsevier user license.
If you are the owner of this record, you can report an update to it here: Report update to this record