Lifelong corticosterone level determines age-related decline in neurogenesis and memory.

Journal article

Ageing is accompanied by an alteration of spatial memory, a decline in hippocampal neurogenesis and a dysregulation of the hypothalamic-pituitary axis (HPA) leading to elevated levels of circulating corticosterone. However, the role of the HPA axis in age-related decline in cognitive functions and in neurogenesis decline remains unclear. We found that suppression of glucocorticoids secretion from midlife to the rest of the animals' life increases neurogenesis in old animals and prevents the e...

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Authors: Montaron, M; Drapeau, E; Dupret, D; Kitchener, P; Aurousseau, C

• Journal: Neurobiology of aging
• Volume: 27
• Issue: 4
• Pages: 645-654
• Publication date: 2006-04-01
• DOI: 10.1016/j.neurobiolaging.2005.02.014
• EISSN: 1558-1497
• ISSN: 0197-4580
• Language: English
• Keywords: Rats, Sprague-Dawley; Male; Neurons; Reaction Time; Organogenesis; Cell Count; Organ Size; Immunohistochemistry; Maze Learning; Ki-67 Antigen; Models, Biological; Adrenal Glands; Memory Disorders; Analysis of Variance; Age Factors; Adrenalectomy; Statistics as Topic; Stereotaxic Techniques; Bromodeoxyuridine; Rats; Aging; Behavior, Animal; Stress, Physiological; Corticosterone; Animals