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A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.

Abstract:

Proteins bearing an endoplasmic reticulum (ER) leader are inserted into the ER followed by cleavage of the signal peptide. Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. Here, we show that an HLA-A(*)0201-restricted epitope from prostate stem cell antigen contains the cleavage site of the ER signal peptidase. The resulting cleavage products fail to bind to HLA-A(*)0201 and ar...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7401065

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
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Journal:
EMBO reports
Volume:
8
Issue:
10
Pages:
945-951
Publication date:
2007-10-01
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Source identifiers:
8168

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