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Thesis

Evaluation of a novel biomarker as a predictor of response, stratification tool, and measure of pharmacology for a disease-modifying osteoarthritis therapeutic

Abstract:

Introduction

Osteoarthritis (OA) is a leading cause of disability in developed countries and is independently associated with increased mortality. Aggrecan degradation is an early process in OA-related cartilage degradation, principally attributed to activity of the aggrecanase ADAMTS-5. One of the products of this activity is ARGS neoepitope which is proposed as a biomarker of OA disease burden. Biomarker measurement and correlation could advance research into effective interventio...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:3dfdc596-fcc0-4f8a-a60e-535282d5b25f
Deposit date:
2016-05-03

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