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Journal article

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

Abstract:

TNF is a key factor in a variety of inflammatory diseases. Here we report that TNF induced pro-inflammatory cytokine synthesis of IL-6 and IL-8 is mediated by the Rho GTPase Rac. TNF induces p42/p44, p54 and p38 MAPK kinase; these kinases have been implicated in control of cytokine synthesis. However, over-expression of a dominant negative form of Rac strongly inhibited TNF-induced p42/44 MAPK kinase activation, but had little effect upon JNK and no effect upon p38 MAPK activity. Another key ...

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Publication status:
Published

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Journal:
Molecular immunology
Volume:
45
Issue:
9
Pages:
2446-2454
Publication date:
2008-05-01
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
Source identifiers:
224697
Language:
English
Keywords:
Pubs id:
pubs:224697
UUID:
uuid:3e087408-4323-44bf-bc45-a05d63123b65
Local pid:
pubs:224697
Deposit date:
2012-12-19

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