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Thesis

Coarse-grained modelling of nucleic acids

Abstract:

This thesis considers coarse-grained models of DNA and RNA, developed in particular to study nanotechnological applications as well as some important biophysical processes. We first introduce sequence-dependent thermodynamics into a previously developed coarse-grained rigid base-pair model of DNA. This model is then used to study sequence-dependent effects in multiple DNA systems including: the heterogeneous stacking transition of single strands, the fraying of a duplex, the effects of...

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Research group:
Ard Louis' group
Oxford college:
University College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:3e1573ec-033c-4971-85e1-ccecd57e7f70
Local pid:
ora:8997
Deposit date:
2014-09-30

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