Journal article
Photochemical probe identification of a small-molecule inhibitor binding site in Hedgehog acyltransferase (HHAT)
- Abstract:
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The mammalian membrane-bound O-acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing. MBOATs are attractive drug targets in cancer and obesity; however, information on the binding site and molecular mechanisms underlying small-molecule inhibition is elusive. This study reports rational development of a photochemical probe to interrogate a novel small-molecule inhibitor binding site in the human MBOAT Hedgehog acyltransferase...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.5MB)
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- Publisher copy:
- 10.1002/anie.202014457
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Authors
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Volume:
- 60
- Issue:
- 24
- Pages:
- 13542-13547
- Publication date:
- 2021-03-26
- Acceptance date:
- 2021-03-02
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1169262
- Local pid:
- pubs:1169262
- Deposit date:
- 2021-03-24
Terms of use
- Copyright holder:
- Lanyon-Hogg et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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