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A motility function for the paraflagellar rod of Leishmania parasites revealed by PFR-2 gene knockouts.

Abstract:

We demonstrate a functional role for the paraflagellar rod (PFR) in motility of Leishmania mexicana. The PFR is a complex cytoskeletal structure running parallel to the axoneme in the flagella of kinetoplastid protozoa. The PFR is composed of a latticework of protein filaments whose major constituents are two related proteins (PFR-1 and PFR-2 in Leishmania). The molecular details of their assembly into PFR filaments are unknown as is the biological function of the PFR. As an approach to under...

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Publication status:
Published

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Journal:
Molecular and biochemical parasitology
Volume:
90
Issue:
1
Pages:
95-109
Publication date:
1997-12-01
DOI:
EISSN:
1872-9428
ISSN:
0166-6851
Source identifiers:
17125
Language:
English
Keywords:
Pubs id:
pubs:17125
UUID:
uuid:3e4ebd20-95d8-44c7-95ef-093f9941ee3f
Local pid:
pubs:17125
Deposit date:
2012-12-19

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