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Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals

Abstract:

To make good decisions, humans need to learn about and integrate different sources of appetitive and aversive information. While serotonin has been linked to value-based decision-making, its role in learning is less clear, with acute manipulations often producing inconsistent results. Here, we show that when the effects of a selective serotonin reuptake inhibitor (SSRI, citalopram) are studied over longer timescales, learning is robustly improved. We measured brain activity with functional ma...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.2000756

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Institution:
University of Oxford
Oxford college:
Christ Church
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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More from this funder
Funding agency for:
Kolling, N
Grant:
89280/Z/09/Z
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Funding agency for:
Rushworth, M
Grant:
WT100973AIA
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Funding agency for:
Scholl, J
Grant:
092759/Z/10/Z
More from this funder
Funding agency for:
Kolling, N
Grant:
89280/Z/09/Z
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
15
Issue:
2
Article number:
e2000756
Publication date:
2017-01-01
Acceptance date:
2017-01-19
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Pubs id:
pubs:673062
UUID:
uuid:3e7022b5-3106-460d-8664-55a4b0d85556
Local pid:
pubs:673062
Deposit date:
2017-01-25

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