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cGMP-phosphodiesterase inhibition prevents hypoxia-induced cell death activation in porcine retinal explants

Abstract:

Retinal hypoxia and oxidative stress are involved in several retinal degenerations including diabetic retinopathy, glaucoma, central retinal artery occlusion, or retinopathy of prematurity. The second messenger cyclic guanosine monophosphate (cGMP) has been reported to be protective for neuronal cells under several pathological conditions including ischemia/hypoxia. The purpose of this study was to evaluate whether the accumulation of cGMP through the pharmacological inhibition of phosphodies...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0166717

Authors


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Role:
Author
ORCID:
0000-0001-8180-1229
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Role:
Author
ORCID:
0000-0003-0635-4961
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Role:
Author
ORCID:
0000-0001-7232-0626
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
11
Issue:
11
Article number:
e0166717
Place of publication:
United States
Publication date:
2016-11-18
Acceptance date:
2016-11-02
DOI:
EISSN:
1932-6203
Pmid:
27861632

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