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A model system to explore the detection limits of antibody-based immuno-SPECT imaging of exclusively intranuclear epitopes

Abstract:

PURPOSE: Imaging of intranuclear epitopes using antibodies tagged to cell penetrating peptides (CPPs) has great potential given its versatility, specificity and sensitivity. However, this process is technically challenging because of the location of the target. Previous research has demonstrated a variety of intranuclear epitopes that can be targeted with antibody-based radioimmunoconjugates (RICs). Here, we developed a controlled expression model of nuclear localised GFP to interrogate the t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2967/jnumed.120.251173

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Publisher:
Society of Nuclear Medicine Publisher's website
Journal:
Journal of Nuclear Medicine Journal website
Volume:
62
Issue:
11
Pages:
1537-1544
Publication date:
2021-03-31
Acceptance date:
2021-02-02
DOI:
EISSN:
2159-662X
ISSN:
0161-5505
Language:
English
Keywords:
Pubs id:
1159836
Local pid:
pubs:1159836
Deposit date:
2021-02-02

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