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Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi

Abstract:

Malawi experienced prolonged use of sulfadoxine/pyrimethamine (SP) as the front-line anti-malarial drug, with early replacement of chloroquine and delayed introduction of artemisinin-based combination therapy. Extended use of SP, and its continued application in pregnancy is impacting the genomic variation of the Plasmodium falciparum population.Whole genome sequence data of P. falciparum isolates covering 2 years of transmission within Malawi, alongside global datasets, were used. More than ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-016-1634-6

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Role:
Author
ORCID:
0000-0002-7818-2348
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Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal
Volume:
15
Issue:
1
Article number:
575
Publication date:
2016-11-29
Acceptance date:
2016-11-23
DOI:
EISSN:
1475-2875
Pmid:
27899115
Source identifiers:
1037111
Language:
English
Keywords:
Pubs id:
pubs:1037111
UUID:
uuid:3eaa351b-bcac-44b1-a50e-ec30753b7fce
Local pid:
pubs:1037111
Deposit date:
2019-09-06

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