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Journal article

The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.

Abstract:

Mutations in genes encoding chromatin-remodeling proteins, such as the ATRX gene, underlie a number of genetic disorders including several X-linked mental retardation syndromes; however, the role of these proteins in normal CNS development is unknown. Here, we used a conditional gene-targeting approach to inactivate Atrx, specifically in the forebrain of mice. Loss of ATRX protein caused widespread hypocellularity in the neocortex and hippocampus and a pronounced reduction in forebrain size. ...

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Publication status:
Published

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Publisher copy:
10.1172/jci22329

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Journal:
Journal of clinical investigation
Volume:
115
Issue:
2
Pages:
258-267
Publication date:
2005-02-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
124959
Language:
English
Keywords:
Pubs id:
pubs:124959
UUID:
uuid:3ebc12e6-e4d0-482f-87e5-780bf2114882
Local pid:
pubs:124959
Deposit date:
2012-12-19

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