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Journal article

PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

Abstract:

Tumour cells can use strategies that make them resistant to nutrient deprivation to outcompete their neighbours. A key integrator of the cell’s responses to starvation and other stresses is amino-acid-dependent mechanistic target of rapamycin complex 1 (mTORC1). Activation of mTORC1 on late endosomes and lysosomes is facilitated by amino-acid transporters within the solute-linked carrier 36 (SLC36) and SLC38 families. Here, we analyse the functions of SLC36 family member, SLC36A4, otherwise k...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/onc.2015.363

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Cancer Research UK More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Oncogene Journal website
Volume:
35
Pages:
3004–3015
Publication date:
2015-10-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Source identifiers:
571025
Pubs id:
pubs:571025
UUID:
uuid:3eed4dcf-4f07-4520-88d4-89fcd811fbba
Local pid:
pubs:571025
Deposit date:
2015-10-19

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