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Mix and match: phenotypic coexistence as a key facilitator of cancer invasion

Abstract:

Invasion of healthy tissue is a defining feature of malignant tumours. Traditionally, invasion is thought to be driven by cells that have acquired all the necessary traits to overcome the range of biological and physical defences employed by the body. However, in light of the ever-increasing evidence for geno- and phenotypic intra-tumour heterogeneity, an alternative hypothesis presents itself: could invasion be driven by a collection of cells with distinct traits that together facilitate the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11538-019-00675-0

Authors


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Institution:
University of Oxford
Department:
Doctoral Training Centre (MPLS)
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0003-4484-8823
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Institution:
University of Oxford
Department:
Mathematical Institute
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0001-9638-7278
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Role:
Author
ORCID:
0000-0002-8888-7747
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Role:
Author
ORCID:
0000-0002-2536-4383
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Publisher:
Springer Publisher's website
Journal:
Bulletin of Mathematical Biology Journal website
Volume:
82
Issue:
1
Article number:
15
Publication date:
2020-01-17
Acceptance date:
2019-12-03
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Source identifiers:
1048779
Language:
English
Keywords:
Pubs id:
pubs:1048779
UUID:
uuid:3eefa64e-45e4-4204-94c6-8d7d013b5da0
Local pid:
pubs:1048779
Deposit date:
2019-12-03

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