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Journal article

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.

Abstract:

The cellular response to DNA damage, mediated by the DNA repair process, is essential in maintaining the integrity and stability of the genome. E2F-7 is an atypical member of the E2F family with a role in negatively regulating transcription and cell cycle progression under DNA damage. Surprisingly, we found that E2F-7 makes a transcription-independent contribution to the DNA repair process, which involves E2F-7 locating to and binding damaged DNA. Further, E2F-7 recruits CtBP and HDAC to the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4161/cc.26078

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Medical Research Council More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Cell Cycle Journal website
Publication date:
2013-08-20
Acceptance date:
2013-08-07
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Source identifiers:
421003
Language:
English
Keywords:
Pubs id:
pubs:421003
UUID:
uuid:3ef96416-1a67-4f9c-b52a-686dec5af48c
Local pid:
pubs:421003
Deposit date:
2015-10-07

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