Journal article
Natural conformational sampling of human TNFα visualized by double electron-electron resonance
- Abstract:
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Double electron-electron resonance in conjunction with site-directed spin labeling has been used to probe natural conformational sampling of the human tumor necrosis factor α trimer. We suggest a previously unreported, predeoligomerization conformation of the trimer that has been shown to be sampled at low frequency. A model of this trimeric state has been constructed based on crystal structures using the double-electron-electron-resonance distances. The model shows one of the protomers to be...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.1016/j.bpj.2017.06.007
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Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Myers, W
Grant:
EP/L011972/1
Bibliographic Details
- Publisher:
- Biophysical Society Publisher's website
- Journal:
- Biophysical Journal Journal website
- Volume:
- 113
- Issue:
- 2
- Pages:
- 371-380
- Publication date:
- 2017-07-25
- Acceptance date:
- 2017-06-06
- DOI:
- EISSN:
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1542-0086
- ISSN:
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0006-3495
- Source identifiers:
-
709609
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:709609
- UUID:
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uuid:3ef9ceb5-b3d9-4772-a6ff-c5b59179fa94
- Local pid:
- pubs:709609
- Deposit date:
- 2017-07-28
Terms of use
- Copyright holder:
- © 2017 Biophysical Society
- Copyright date:
- 2017
- Notes:
-
This is an open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
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