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Journal article

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

Abstract:

Background: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets. Results: Using functional genomics, we identified stearoyl-CoA desaturase (SCD), an enzyme that controls synthesis of unsaturated fatty acids, as essential in breast ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s40170-016-0146-8

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Cancer Research UK More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Cancer and Metabolism Journal website
Volume:
4
Issue:
1
Pages:
6
Publication date:
2016-04-01
Acceptance date:
2016-03-07
DOI:
EISSN:
2049-3002
Pmid:
27042297
Source identifiers:
613984
Language:
English
Keywords:
Pubs id:
pubs:613984
UUID:
uuid:3efc5690-3ccd-4e3c-8fcb-e1a40a36c935
Local pid:
pubs:613984
Deposit date:
2017-06-14

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