Journal article
State-dependent network connectivity determines gating in a K+ channel.
- Abstract:
-
X-ray crystallography has provided tremendous insight into the different structural states of membrane proteins and, in particular, of ion channels. However, the molecular forces that determine the thermodynamic stability of a particular state are poorly understood. Here we analyze the different X-ray structures of an inwardly rectifying potassium channel (Kir1.1) in relation to functional data we obtained for over 190 mutants in Kir1.1. This mutagenic perturbation analysis uncovered an exten...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.str.2014.04.018
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Authors
Bibliographic Details
- Journal:
- Structure (London, England : 1993)
- Volume:
- 22
- Issue:
- 7
- Pages:
- 1037-1046
- Publication date:
- 2014-07-01
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Source identifiers:
-
474807
Item Description
- Language:
- English
- Pubs id:
-
pubs:474807
- UUID:
-
uuid:3f16aa53-5819-442c-8a38-4328583415e4
- Local pid:
- pubs:474807
- Deposit date:
- 2014-07-26
Terms of use
- Copyright date:
- 2014
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