Thesis
Identification and characterisation of homologous recombination genes in Schizosaccharomyces pombe
- Abstract:
-
DNA double-strand breaks (DSBs) are highly genotoxic lesions, which can promote chromosomal rearrangements and tumorigenesis through oncogene activation or loss of heterozygosity (LOH) at tumour suppressor loci. To identify new genes involved in DSB repair and genome stability, an S. pombe deletion library was screened for mutants which exhibited sensitivity to the DNA damaging agents bleomycin and/or MMS. 192 mutants were isolated which exhibited increased sensitivity to one or both of th...
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Authors
Contributors
+ Humphrey, T
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:3f2f12d1-64b9-496a-ba1e-5c464e89c7b7
- Local pid:
- ora:5633
- Deposit date:
- 2011-08-15
Terms of use
- Copyright holder:
- Moss, J
- Copyright date:
- 2011
- Notes:
- This thesis is not currently available in ORA.
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