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Thesis

Collaboration of Ezh2 and Runx1 inactivating mutations in malignant haematopoiesis

Abstract:

Extensive efforts have shed light on the identity and biology of cancer stem cells, required and sufficient for the propagation of hematological malignancies and solid tumours. Much less is understood about the closely related issue as to the identity and properties of the normal stem and progenitor cells targeted by oncogenic lesions, and how the nature of the targeted cell might impact on the biology and clinical picture of the resulting cancer. To address this, we developed a mouse mode...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3f3b18b1-5875-42ed-b025-cf0dd457b99f
Deposit date:
2018-02-26

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