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Cullin ring ubiquitin ligases (CRLs) in cancer: responses to ionizing radiation (IR) treatment

Abstract:

Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer types, including disseminated and aggressive diseases in the palliative setting. Radiotherapy efficacy could be improved in combination with drugs that regulate the ubiquitin-proteasome system (UPS), many of which are currently being tested in clinical trials. The UPS operates through the covalent attachment of ATP-activated ubiquitin molecules onto substrates following the transfer of ubiquitin from...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fphys.2019.01144

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
Wolfson College
Role:
Author
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Physiology Journal website
Volume:
10
Pages:
1144
Publication date:
2019-10-01
Acceptance date:
2019-08-22
DOI:
EISSN:
1664-042X
Pmid:
31632280
Source identifiers:
1064144
Language:
English
Keywords:
Pubs id:
pubs:1064144
UUID:
uuid:3f49c966-dc59-4ac8-b499-41719f914fcb
Local pid:
pubs:1064144
Deposit date:
2019-11-04

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