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Thesis

Roles of BRCA1 and BRCA2 in DNA replication and genome stability

Abstract:

Genomic instability is a hallmark of cancer. The tumour suppressors BRCA1 and BRCA2 play key roles in genome integrity by promoting homologous recombination DNA repair and replication fork stability. Deficiency in these functions has been described as the Achilles heel of BRCA-defective tumours. This provides an important rationale for further exploring the roles of BRCA1 and BRCA2 in DNA replication and genome stability.

G-quadruplexes, alternative DNA structures formed by guanine-...

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
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Funding agency for:
Zimmer, J
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:3f595c71-7b99-4133-b215-dd5d5f19463f
Deposit date:
2017-12-20

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