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Thesis

Investigating the role of RAD51 phosphorylation during the cell cycle

Abstract:

The RAD51 recombinase safeguards genomic integrity by promoting double-strand break repair and replication fork protection. PLK1-dependent RAD51 phosphorylation contributes to RAD51 recruitment at DNA double strand breaks and stalled replication forks. During an unperturbed cell cycle, RAD51 phosphorylation peaks in late G2 phase and mitosis, suggesting a role for (phosphorylated) RAD51 during the later stages of the cell cycle.

In this thesis, CRISPR/Cas9 RAD51 phospho-mutants ...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

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Role:
Supervisor
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Funding agency for:
Wassing, I
Grant:
Project No: BRT00020 Task Number: BV00.06
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:3f92cd0a-d0b8-4303-adee-80f22560dbdd
Deposit date:
2019-07-01

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