Journal article
In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.
- Abstract:
-
Adjuvants are substances that enhance immune responses and thus improve the efficacy of vaccination. Few adjuvants are available for use in humans, and the one that is most commonly used (alum) often induces suboptimal immunity for protection against many pathogens. There is thus an obvious need to develop new and improved adjuvants. We have therefore taken an approach to adjuvant discovery that uses in silico modeling and structure-based drug-design. As proof-of-principle we chose to target ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.0803453105
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Authors
Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 105
- Issue:
- 29
- Pages:
- 10221-10226
- Publication date:
- 2008-07-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
34309
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:34309
- UUID:
-
uuid:3fa235bd-d895-4260-82c1-259609e8b2f2
- Local pid:
- pubs:34309
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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