Evidence for association between endothelial nitric oxide synthase gene polymorphism (G894T) and inflammatory markers: the ATTICA study.

Journal article

BACKGROUND: We evaluated the effect of the point mutation of guanine to thymine at nucleotide position 894 (G894T) of the endothelial nitric oxide synthase (eNOS) gene on inflammatory and oxidative stress markers. METHODS: We studied genetic information from 270 men (18-87 years old) and 325 women (18-89 years old). Participants without any clinical evidence of cardiovascular or other atherosclerotic disease were randomly selected from the general population according to the age-sex distribu...

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Authors: Chrysohoou, C; Panagiotakos, D; Pitsavos, C; Antoniades, C; Skoumas, J

• Journal: American heart journal
• Volume: 148
• Issue: 4
• Pages: 733-738
• Publication date: 2004-10-01
• DOI: 10.1016/j.ahj.2004.04.022
• EISSN: 1097-6744
• ISSN: 0002-8703
• Language: English
• Keywords: Biological Markers; Middle Aged; Point Mutation; Adolescent; Aged; Aged, 80 and over; Adult; Genetic Predisposition to Disease; Cardiovascular Diseases; Male; Fibrinogen; C-Reactive Protein; Nitric Oxide Synthase Type III; Oxidative Stress; Cross-Sectional Studies; Homocysteine; Nitric Oxide Synthase; Cholesterol, LDL; Serum Amyloid A Protein; Leukocyte Count; Humans; Female; Polymorphism, Genetic