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Journal article

Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography

Abstract:

Niemann-Pick C disease (NPC) is an autosomal recessive lysosomal storage disorder resulting from mutations in the NPC1 (95% of cases) or NPC2 genes. Disturbance of copper homeostasis has been reported in NPC1 disease. In this study we have used whole-body positron emission tomography (PET) and brain electronic autoradiography with copper-64 (64Cu), in the form of the copper(II) bis(thiosemicarbazonato) complex 64Cu-GTSM, to image short-term changes in copper trafficking after intravenous inje...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10534-019-00185-5

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Publisher:
Springer Netherlands Publisher's website
Journal:
BioMetals Journal website
Volume:
32
Issue:
2
Pages:
293–306
Publication date:
2019-03-07
Acceptance date:
2019-02-25
DOI:
EISSN:
1572-8773
ISSN:
0966-0844
Source identifiers:
976208
Keywords:
Pubs id:
pubs:976208
UUID:
uuid:3fbaf265-9663-4391-b156-328b6300bf10
Local pid:
pubs:976208
Deposit date:
2019-02-25

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