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Naturally occurring glucokinase mutations are associated with defects in posttranslational S-nitrosylation.

Abstract:

Posttranslational activation of glucokinase (GCK) through S-nitrosylation has been recently observed in the insulin-secreting pancreatic beta-cell; however, the function of this molecular mechanism in regulating the physiology of insulin secretion is not well understood. To more fully understand the function of posttranslational regulation of GCK, we examined two naturally occurring GCK mutations that map to residues proximal to the S-nitrosylated cysteine and cause mild fasting hyperglycemia...

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Publisher copy:
10.1210/me.2009-0138

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Journal:
Molecular endocrinology (Baltimore, Md.)
Volume:
24
Issue:
1
Pages:
171-177
Publication date:
2010-01-01
DOI:
EISSN:
1944-9917
ISSN:
0888-8809
Source identifiers:
5076

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