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Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine

Abstract:

Creatine buffers cellular ATP via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine synthesis. AGAT-/- mice fed a creatine-free diet have a whole body creatine-deficiency. We hypothesised that AGAT-/- mice would develop cardiac dysfunction and rescue by dietary creatine would impl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvx242

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Atzler, D
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Funding agency for:
Choe, C
Grant:
No. 5/86
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Funding agency for:
Isbrandt, D
Grant:
DFG, CH872/1-1
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Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
114
Issue:
3
Pages:
417-430
Publication date:
2017-12-11
Acceptance date:
2017-11-28
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pmid:
29236952
Language:
English
Keywords:
Pubs id:
pubs:810891
UUID:
uuid:4006a608-cfae-4a3d-afb2-a9a6ae7b23e7
Local pid:
pubs:810891
Deposit date:
2017-12-15

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