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Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.

Abstract:

Although it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotypes. Only Bw4(+) tetramers bound KIR3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and all four KIR3DL1 allotypes bound to one or more HLA-A*2402 tetramers, but with di...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.178.1.33

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Journal:
Journal of Immunology
Volume:
178
Issue:
1
Pages:
33-37
Publication date:
2007-01-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
95274

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