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Journal article

Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors.

Abstract:

Immunoglobulin T-cell receptors (IgTCRs) combine the specificity of antibodies with the potency of cellular killing by grafting antibody recognition domains onto TCR signaling chains. IgTCR-modified T cells are thus redirected to kill tumor cells based on their expression of intact antigen on cell surfaces, bypassing the normal mechanism of activation through TCR-peptide-major histocompatibility complex (MHC) recognition. Melanoma is one of the most immunoresponsive of human cancers and has s...

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Publication status:
Published

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Publisher copy:
10.1038/sj.neo.7900108

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Neoplasia (New York, N.Y.)
Volume:
2
Issue:
5
Pages:
449-459
Publication date:
2000-01-01
DOI:
EISSN:
1476-5586
ISSN:
1522-8002
Source identifiers:
60632

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