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Journal article

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Abstract:

Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic variants in the tyrosine kinase 2 (TYK2) gene, which is differentially associated with common autoimmune diseases, currently obscures the potential of TYK2 as a therapeutic target. We aimed to resolve this c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scitranslmed.aag1974

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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More from this funder
Grant:
106130/Z/14/Z
100308/Z/12/Z
100956/Z/13/Z
Medical Research Council More from this funder
Rosetrees Trust More from this funder
Alan and Babette Sainsbury Charitable Fund More from this funder
Oak Foundation More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
8
Issue:
363
Publication date:
2016-11-02
Acceptance date:
2016-09-19
DOI:
ISSN:
1946-6242 and 1946-6234
Source identifiers:
656757
Language:
English
Keywords:
Pubs id:
pubs:656757
UUID:
uuid:4094051d-4bfd-4a71-bbaa-0e87c9cf03f9
Local pid:
pubs:656757
Deposit date:
2016-11-02

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