Journal article
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
- Abstract:
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Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic variants in the tyrosine kinase 2 (TYK2) gene, which is differentially associated with common autoimmune diseases, currently obscures the potential of TYK2 as a therapeutic target. We aimed to resolve this c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 1.4MB)
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- Publisher copy:
- 10.1126/scitranslmed.aag1974
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Authors
Funding
Medical Research Council
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Rosetrees Trust
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Alan and Babette Sainsbury Charitable Fund
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Oak Foundation
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Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine Journal website
- Volume:
- 8
- Issue:
- 363
- Publication date:
- 2016-11-02
- Acceptance date:
- 2016-09-19
- DOI:
- ISSN:
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1946-6242 and 1946-6234
- Source identifiers:
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656757
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:656757
- UUID:
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uuid:4094051d-4bfd-4a71-bbaa-0e87c9cf03f9
- Local pid:
- pubs:656757
- Deposit date:
- 2016-11-02
Terms of use
- Copyright holder:
- Dendrou et al
- Copyright date:
- 2016
- Notes:
- 2016 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.
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