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The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.

Abstract:

Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFandbeta;, respectively) are known rate-limiting regulators of seam cell proliferation. Here, we show, using a combination of comparative genomics and DNA binding assays, that bro-1 e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002200

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
MRC Capacity Building Studentship More from this funder
NIH National Center for Research Resources More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
8
Article number:
e1002200
Publication date:
2011-08-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
205879

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