Journal article
The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells.
- Abstract:
-
OBJECTIVE: To test whether ETS-related gene (Erg) inhibits tumor necrosis factor (TNF)-α-dependent endothelial activation and inflammation. METHODS AND RESULTS: Endothelial activation underlies many vascular diseases, including atherosclerosis. Endothelial activation by proinflammatory cytokines decreases expression of the ETS transcription factor Erg. By using human umbilical vein endothelial cells (HUVECs), we showed that Erg overexpression by adenovirus (AdErg) repressed basal and TNF-α-in...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/atvbaha.110.216473
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Bibliographic Details
- Journal:
- Arteriosclerosis, thrombosis, and vascular biology
- Volume:
- 31
- Issue:
- 1
- Pages:
- 142-150
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1524-4636
- ISSN:
-
1079-5642
- Source identifiers:
-
230218
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:230218
- UUID:
-
uuid:40c3df1f-06bf-4548-b157-25cd461f35e1
- Local pid:
- pubs:230218
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2011
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