Journal article icon

Journal article

Adventures in defining roles of oxygenases in the regulation of protein biosynthesis

Abstract:

The 2‐oxoglutarate (2OG) dependent oxygenases were first identified as having roles in the post‐translational modification of procollagen in animals. Subsequently in plants and microbes, they were shown to have roles in the biosynthesis of many secondary metabolites, including signalling molecules and the penicillin/cephalosporin antibiotics. Crystallographic studies of microbial 2OG oxygenases and related enzymes, coupled to DNA sequence analyses, led to the prediction that 2OG oxygenases ar...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/tcr.201800056

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-0290-6565
More from this funder
Funding agency for:
Walport, L
Grant:
Marie Skłodowska-Curie grant 657292
Biotechnological and Biological Research Council More from this funder
Medical Research Council More from this funder
Expand funders...
Publisher:
Wiley Publisher's website
Journal:
Chemical Record Journal website
Volume:
18
Issue:
12
Pages:
1760-1781
Publication date:
2018-08-27
Acceptance date:
2018-07-17
DOI:
ISSN:
1527-8999
Source identifiers:
871377
Keywords:
Pubs id:
pubs:871377
UUID:
uuid:40da68a2-ee1a-4d71-aee7-1a31c281f2f4
Local pid:
pubs:871377
Deposit date:
2018-07-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP