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Journal article

Synthesis of chemically modified DNA

Abstract:

Naturally occurring DNA is encoded by the four nucleobases adenine, cytosine, guanine and thymine. Yet minor chemical modifications to these bases, such as methylation, can significantly alter DNA function, and more drastic changes, such as replacement with unnatural base pairs, could expand its function. In order to realize the full potential of DNA in therapeutic and synthetic biology applications, our ability to 'write' long modified DNA in a controlled manner must be improved. This review...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1042/BST20160051

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Publisher:
Portland Press Publisher's website
Journal:
Biochemical Society Transactions Journal website
Volume:
44
Issue:
3
Pages:
709-715
Publication date:
2016-06-09
Acceptance date:
2016-03-24
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Pmid:
27284032
Source identifiers:
628374
Language:
English
Keywords:
Pubs id:
pubs:628374
UUID:
uuid:40ea480a-9c8a-414d-948b-c265a719f64e
Local pid:
pubs:628374
Deposit date:
2017-02-13

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