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Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair

Abstract:

It has previously been shown that transcription greatly enhances recombination in mammalian cells. However, the proteins involved in catalysing this process and the recombination pathways involved in transcription-associated recombination (TAR) are still unknown. It is well established that both the BRCA2 protein and the RAD51 paralog protein XRCC2 are required for homologous recombination. Here, we show that the BRCA2 protein is also required for TAR, while the XRCC2 protein is not involved....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkn971

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Institution:
Stockholm University
Department:
Genetics,Microbiology and Toxicology
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author
Swedish Cancer Society More from this funder
Swedish Children's Cancer Foundation More from this funder
Swedish Research Council More from this funder
Sven and Lilly Lawski Foundation More from this funder
Swedish Pain Relief Foundation More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
37
Issue:
2
Pages:
405–412
Publication date:
2009-02-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Subjects:
UUID:
uuid:40f3018a-02c1-476a-83ae-345b7b97a2cd
Local pid:
ora:8068
Deposit date:
2014-02-24

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