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Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

Abstract:

OBJECTIVES: To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion. RESEARCH DESIGN AND METHODS: Haploinsufficiency of the insulin receptor and associated mild insulin resistance has been used to sensitize an N-ethyl-N-nitrosourea (ENU) screen to identify novel mutations resulting in impaired glucose tolerance and diabetes. The new impaired glucose tolerance 4 (IGT4) model was selected using an intraperitoneal glucose tolera...

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Publication status:
Published

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Publisher copy:
10.2337/db07-0337

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Journal:
Diabetes
Volume:
57
Issue:
8
Pages:
2234-2244
Publication date:
2008-08-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
110456

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