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Metformin as adjunctive therapy for dengue in overweight and obese patients: a protocol for an open-label clinical trial (MeDO)

Abstract:
Background: Dengue is a disease of major global importance. While most symptomatic infections are mild, a small proportion of patients progress to severe disease with risk of hypovolaemic shock, organ dysfunction and death. In the absence of effective antiviral or disease modifying drugs, clinical management is solely reliant on supportive measures. Obesity is a growing problem among young people in Vietnam and is increasingly recognised as an important risk factor for seve... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.12688/wellcomeopenres.16053.2

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Role:
Author
ORCID:
0000-0002-5960-7849
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Role:
Author
ORCID:
0000-0002-1840-0868
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Role:
Author
ORCID:
0000-0003-2684-3041
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Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
5
Article number:
160
Publication date:
2021-02-08
Acceptance date:
2021-02-24
DOI:
EISSN:
2398-502X
Pmid:
33083561
Language:
English
Keywords:
Pubs id:
1139463
Local pid:
pubs:1139463
Deposit date:
2021-04-20

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