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Journal article

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

Abstract:

Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs) that bypass the specific mechanisms but act as master keys to open K+ channels gated at their selectivity filter (SF), including many two-pore domain K+ (K2P

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aav0569

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
363
Issue:
6429
Pages:
875-880
Publication date:
2019-02-22
Acceptance date:
2019-01-28
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Source identifiers:
976205
Language:
English
Pubs id:
pubs:976205
UUID:
uuid:413f89cf-1e16-47fb-83e1-5a0b532b5cab
Local pid:
pubs:976205
Deposit date:
2019-02-25

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