Journal article
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
- Abstract:
-
Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs) that bypass the specific mechanisms but act as master keys to open K+ channels gated at their selectivity filter (SF), including many two-pore domain K+ (K2P
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 363
- Issue:
- 6429
- Pages:
- 875-880
- Publication date:
- 2019-02-22
- Acceptance date:
- 2019-01-28
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
Item Description
- Language:
- English
- Pubs id:
-
pubs:976205
- UUID:
-
uuid:413f89cf-1e16-47fb-83e1-5a0b532b5cab
- Local pid:
- pubs:976205
- Source identifiers:
-
976205
- Deposit date:
- 2019-02-25
Terms of use
- Copyright holder:
- Schewe et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: https://doi.org/10.1126/science.aav0569
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