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Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Abstract:

Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflammatory bowel disease (IBD). A vital cytokine in regulating intestinal T cells is transforming growth factor-β (TGFβ), which is secreted by cells as a latent complex that requires activation to function. However, how TGFβ activation is regulated in the human intestine, and how such pathways are altered in IBD is completely unknown. Here we show that a key activator of TGFβ, integrin αvβ8, is hig...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mi.2016.94

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Grant:
CASEPhDstudentship;Diet
ResearchIndustryClubgrant
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Grant:
Stepping Stones Fellowship (097820/Z/11/B)
088785/Z/09/Z
Publisher:
Springer Nature Publisher's website
Journal:
Mucosal Immunology Journal website
Publication date:
2016-10-26
Acceptance date:
2016-08-26
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
Source identifiers:
656945
Language:
English
Keywords:
Pubs id:
pubs:656945
UUID:
uuid:4166de0f-4dbd-4c3d-b97f-9adb8e2b4335
Local pid:
pubs:656945
Deposit date:
2017-01-03

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