Determination of an optimally sensitive and specific Chemical Exchange Saturation Transfer MRI quantification metric in relevant biological phantoms
The purpose of this study was to develop realistic phantom models of the intracellular environment of metastatic breast tumour and naïve brain, and using these models determine an analysis metric for quantification of CEST-MRI data which is sensitive to only labile proton exchange rate and concentration. The ability of the optimal metric to quantify pH differences in the phantoms was also evaluated.
Novel phantom models were produced, by adding perchloric acid extracts of eith...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- Baldwin et al
- Copyright date:
- © 2016 The Authors NMR in Biomedicine Published by John Wiley and Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- CC Attribution (CC BY)
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